Profile

• Leonteios School of Athens, Athens, Greece
• MD, Medical School, National and Kapodistrian University of Athens, Greece
• Clinical Internship in General Surgery, NewYork-Presbyterian Hospital, Columbia University, New York, USA
• MSc in Surgical Innovation, Imperial College London, London, United Kingdom
• PhD Candidate, Medical School, National and Kapodistrian University of Athens

“Biochemical Markers for the Early Diagnosis of Gestational Diabetes Mellitus” Medical School, National and Kapodistrian University of Athens

• Resident in General Surgery and Breast Surgery, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
• Resident in Obstetrics and Gynecology, First Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Alexandra General Hospital, Athens, Greece
• Fellow in Maternal–Fetal Medicine, Harris Birthright Centre, Fetal Medicine Research Institute, King’s College Hospital, London, United Kingdom
• Postdoctoral Scholar in Fetal Surgery, UCSF Center for Maternal-Fetal Precision Medicine, University of California San Francisco, San Francisco, California, USA
• Visiting Fellow in Fetal Surgery, Center for Fetal Therapy, Johns Hopkins Hospital, Baltimore, Maryland, USA

• Fetal medicine and prenatal screening
• Clinical surveillance and management of twin pregnancies
• Prevention, early diagnosis, and clinical management of preterm birth
• Fetal therapies and intrauterine interventions
• Placental disorders and fetal complications

• Successful prenatal delivery of a therapeutic antisense oligonucleotide for treatment of Angelman Syndrome. Maria Clarke, Lea Lentz, Laura Remesal Gomez, Georgia Kirn, Jasmine Valencia, Antonia Varthaliti, Danielle Tan, Sarah Christian, Stephan J. Sanders, Scott Dindot, Saul Villeda, Tippi C. MacKenzie. ASGCT 25th Annual Meeting, 16-19 May 2022, Washington DC, USA.
• A Prenatal Antisense Oligonucleotide Therapy for Angelman Syndrome in a Mouse Model, Maria T. Clarke, Laura Remesal Gomez, Lea Lentz, Jasmine Wu, Shalini Namduri, Antonia Varthaliti, Georgia Kirn, Danielle Tan, Sarah Christian, Stephan J. Sanders, Scott Dindot, Saul Villeda, Tippi C. MacKenzie. FAST 15th Annual Global Science Summit and Gala, 2-3 December 2022, Miami, Florida, USA.
• Prenatal Administration of AAV9-GFP in Fetal Lambs Results in Widespread
• Biodistribution and Transduction of Female, but Not Male, Germ Cells. Beltran Borges, Antonia Varthaliti, Marisa E. Schwab, Maria Clarke, Akos Herzeg, Christopher Pivetti, Nalin Gupta, Cathryn Cadwell, Ghiabe Henri Guibinga, Shirley Phillips, Tony Del Rio, Fatih Ozsolak, Denise Imai-Leonard, Diana J. Laird, Lingling Kong, Charlotte Sumner, Tippi C. MacKenzie. May 2023, Los Angeles, California, USA
• Prenatal Testing of Antisense Oligonucleotides in Fetal Mouse and Sheep Models for the Treatment of Rare Neurologic Conditions. Maria T. Clarke, Beltran Borges, Akos Herzeg, Christopher Pivetti, Nalin Gupta, Laura Remesal Gomez, Lea Lentz, Danielle Tan, David Young, Shalini Namduri, Jasmine Wu, Antonia Varthaliti, Georgia Kirn, Stephan J. Sanders, Scott Dindot, Saul Villeda, Charlotte Sumner, Frank Bennet, Tippi C. MacKenzie. Podium presentation, iFETUS Annual Meeting May 2023.
• Antibiotic prophylaxis during delivery. Is overuse of antibiotics still a problem? Karasmani C., Psarris A., Varthaliti A., Theodora M., Antsaklis P., Syndos M., Domali E., Thomakos N., Daskalakis G. 5th ISIDOG Congress, 19-22 October 2023, Athens, Greece.

https://pubmed.ncbi.nlm.nih.gov/?term=varthaliti+a&sort=date

• Buerger O, Elger T, Varthaliti A, Syngelaki A, Wright A, Nicolaides KH. First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies. J Clin Med. 2021 Aug 25;10(17):3814. doi: 10.3390/jcm10173814. PMID: 34501262; PMCID: PMC8432220.
• Daskalakis G, Psarris A, Koutras A, Fasoulakis Z, Prokopakis I, Varthaliti A, Karasmani C, Ntounis T, Domali E, Theodora M, Antsaklis P, Pappa KI, Papapanagiotou A. Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications. Children (Basel). 2023 May 22;10(5):907. doi: 10.3390/children10050907. PMID: 37238455; PMCID: PMC10217143.
• Pergialiotis V, Sapantzoglou I, Rodolaki K, Varthaliti A, Theodora M, Antsaklis P, Thomakos N, Stavros S, Daskalakis G, Papapanagiotou A. Maternal and neonatal outcomes following magnesium sulfate in the setting of chorioamnionitis: a meta-analysis. Arch Gynecol Obstet. 2024 Mar;309(3):917-927. doi: 10.1007/s00404-023-07221-3. Epub 2023 Sep 28. PMID: 37768342; PMCID: PMC10866770.
• Panagiotopoulos M, Pergialiotis V, Trimmi K, Varthaliti A, Koutras A, Antsaklis P, Daskalakis G. Differences in cervical length during the second trimester among normal weight, overweight and obese women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol X. 2024 Feb 15;21:100291. doi: 10.1016/j.eurox.2024.100291. PMID: 38419650; PMCID: PMC10900401.
• Borges B, Varthaliti A, Schwab M, Clarke MT. Pivetti C, Gupta N, Cadwell CR, Guibinga G, Phillips S, Del Rio T, Ozsolak F, Imai-Leonard D, Kong L, Laird DJ, Herzeg A, Sumner CJ, MacKenzie TC. Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus. Mol Ther Methods Clin Dev. 2024 May 3; S2329-0501(24)00079-2, doi.org/10.1016/j.omtm.2024.101263.
• Varthaliti A, Fasoulakis Z, Lygizos V, Zolota V, Chatziioannou MI, Daskalaki MA, Daskalakis G, Antsaklis P. Safety of Obstetric Ultrasound: Mechanical and Thermal Indexes—A Systematic Review. Journal of Clinical Medicine. 2024; 13(21):6588. doi.org/10.3390/jcm13216588.
• Varthaliti A, Rodolaki K, Lygizos V, Vlachos DE, Thomakos N, Sioutis D, Daskalakis G, Pergialiotis V. Neurodevelopmental Outcomes in the Offspring of Women with Vitamin D Deficiency and Women Who Received Vitamin D Supplementation During Pregnancy. Nutrients. 2025 Mar 11;17(6):978. doi: 10.3390/nu17060978. PMID: 40290028; PMCID: PMC11944307.
• Varthaliti A, Pergialiotis V, Theodora M, Lygizos V, Daskalaki MA, Antsaklis P, Daskalakis G. Advances in Fetal Surgery: A Narrative Review of Therapeutic Interventions and Future Directions. Medicina (Kaunas). 2025 Jun 24;61(7):1136. doi: 10.3390/medicina61071136. PMID: 40731766; PMCID: PMC12300766.
• Varthaliti A, Lygizos V, Fanaki M, Pergialiotis V, Papapanagiotou A, Pappa K, Theodora M, Daskalaki MA, Antsaklis P, Daskalakis G. The Role of IL-6 and TNF-α as Early Biomarkers in the Prediction and Diagnosis of Gestational Diabetes Mellitus. Biomedicines. 2025 Jul 2;13(7):1627. doi: 10.3390/biomedicines13071627. PMID: 40722699; PMCID: PMC12292796.
• Varthaliti A, Pergialiotis V, Lygizos V, Antsaklis P, Theodora M, Vlachos DE, Daskalaki MA, Thomakos N, Daskalakis G. First-trimester maternal serum PAPP-A levels and hyperemesis gravidarum: unraveling the link - a meta-analysis. J Perinat Med. 2025 Sep 1. doi: 10.1515/jpm-2025-0169. Epub ahead of print. PMID: 40886158.
• Varthaliti A, Psarris A, Koutroumanis P, Gkiaourakis G, Daskalaki MA, Antsaklis P, Daskalakis G, Theodora M. Prognostic Significance of Serial Ultrasonography in Placenta Accreta Spectrum and Its Impact on Perinatal Outcomes. Medicina (Kaunas). 2025 Sep 5;61(9):1612. doi: 10.3390/medicina61091612. PMID: 41011001; PMCID: PMC12471937.

• Fetal Medicine Foundation (FMF)
• International Society of Ultrasound in Obstetrics and Gynecology (ISUOG)
• Hellenic Society of Obstetrics and Gynecology
• Hellenic Society of Perinatal Medicine
• Hellenic Society of Ultrasound in Obstetrics and Gynecology
• Hellenic Society of Obstetric and Gynecologic Infections
• General Medical Council (GMC)
• Athens Medical Association

• ASPRE-T trial (FMF): Coordinator at Alexandra General Hospital
• Complications of mopnochorionic twin pregnancies (TTTS, TAPS, sFGR, TRAP)
• Advanced fetal therapies and intrauterine interventions.
• In utero gene therapy for the treatment of monogenic disorders.
• Maternal–Fetal Medicine and management of high-risk pregnancies
• Preterm birth